Epitalon

About Epitalon

Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) designed from the amino acid composition of epithalamin, a polypeptide extract of bovine pineal gland. It is studied in cell-culture and animal research, including work on telomerase activity in cultured human cells.

Also known as: Epithalon, Epithalone, AEDG.

Read more in the Research Library: Epitalon: a research overview.

For laboratory research use only. Not for human or veterinary use.

Epitalon research

Background

Epitalon has the sequence Ala-Glu-Asp-Gly (AEDG). It was developed by Vladimir Khavinson’s group in St. Petersburg as a defined synthetic peptide based on the amino acid composition of epithalamin, a mixed peptide extract from bovine pineal gland tissue.

Much of the published work on Epitalon comes from the group that developed it, including the 2003 cell-culture and mouse studies cited below.

Epitalon has not been evaluated by the FDA.

Selected literature

1. Cultured human cells

   Reported that adding Epitalon to cultured human somatic cells increased telomerase activity and telomere length.

   Khavinson VK et al., Bull Exp Biol Med, 2003 · PubMed
2. Female SHR mice

   Examined biomarkers of ageing, lifespan and spontaneous tumour incidence in female SHR mice given Epitalon.

   Anisimov VN et al., Biogerontology, 2003 · PubMed

Summaries describe what each cited paper reports in its own model system. They are not claims about the effects of this product.

For laboratory research use only. Not for human or veterinary use.

Storage & handling

Lyophilized powder

Store the sealed vial at −20 °C (−4 °F), the temperature it ships at.

Light & moisture

Keep the vial sealed and away from light and moisture.

Before opening

Let a sealed vial come to room temperature before opening, to limit condensation inside the vial.

Shipping

Shipped cold-chain.

Batch details

Always follow the label and your batch’s Certificate of Analysis.

Specifications