A very small compound, just three amino acids (lysine-proline-valine), derived from a fragment of the hormone alpha-MSH. Despite its size, it's been studied for anti-inflammatory properties, including in research models examining gut inflammation.
KPV is a tripeptide (Lys-Pro-Val) that corresponds to the C-terminal fragment, residues 11 to 13, of α-melanocyte-stimulating hormone (α-MSH). It has been studied in cell-culture and mouse research, including work on its uptake by the peptide transporter PepT1.
Also known as: α-MSH(11–13), Lys-Pro-Val.
Read more in the Research Library: KPV: a research overview.
For laboratory research use only. Not for human or veterinary use.
KPV has the sequence Lys-Pro-Val. α-MSH is a 13-amino-acid neuropeptide cut from the larger precursor protein proopiomelanocortin (POMC), and KPV is its C-terminal end.
The published work cited here is preclinical. It includes cell-based studies of how KPV enters cells through the peptide transporter PepT1, and mouse studies in induced models of intestinal inflammation.
KPV has not been evaluated by the FDA.
Examined whether KPV enters intestinal epithelial and immune cells through the peptide transporter PepT1, and examined its effect in two mouse models of induced colitis.
Dalmasso G et al., Gastroenterology, 2008 PubMedReview of α-MSH and its related tripeptides, including KPV, in cell and animal studies.
Brzoska T et al., 2008 (review) PubMedSummaries describe what each cited paper reports in its own model system. They are not claims about the effects of this product.
For laboratory research use only. Not for human or veterinary use.
| Compound | KPV |
|---|---|
| Class | Tripeptide fragment of α-MSH |
| Sequence | Lys-Pro-Val (KPV) |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.4 g/mol |
| CAS number | 67727-97-3 |
| Form | Lyophilized powder |
| Purity | 99.029% — see the COA for this batch’s full report |
| Amount per vial | 10 mg, 30 mg |
| Batch | KP-307 |
| Certificate of analysis | View the COA (PDF) |