KPV: A Research Overview
KPV is a tripeptide (Lys-Pro-Val) that corresponds to the C-terminal fragment, residues 11 to 13, of α-melanocyte-stimulating hormone (α-MSH). It has been studied in cell-culture and mouse research, including work on its uptake by the peptide transporter PepT1.
Chemical identity
| Compound | KPV |
|---|---|
| Also known as | α-MSH(11–13), Lys-Pro-Val |
| Class | Tripeptide fragment of α-MSH |
| Sequence | Lys-Pro-Val (KPV) |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.4 g/mol |
| CAS number | 67727-97-3 |
Background
KPV has the sequence Lys-Pro-Val. α-MSH is a 13-amino-acid neuropeptide cut from the larger precursor protein proopiomelanocortin (POMC), and KPV is its C-terminal end.
The published work cited here is preclinical. It includes cell-based studies of how KPV enters cells through the peptide transporter PepT1, and mouse studies in induced models of intestinal inflammation.
KPV has not been evaluated by the FDA.
What the published literature reports
- Intestinal cells and mouse models
Examined whether KPV enters intestinal epithelial and immune cells through the peptide transporter PepT1, and examined its effect in two mouse models of induced colitis.
Dalmasso G et al., Gastroenterology, 2008 PubMed - Review
Review of α-MSH and its related tripeptides, including KPV, in cell and animal studies.
Brzoska T et al., 2008 (review) PubMed
How to read this literature
The work cited above spans intestinal cells and mouse models, review. Findings from cell culture or animal models, and review articles that summarise them, do not establish how a compound behaves in other systems. Each citation links to the original record so you can read it directly.
Summaries describe what each cited paper reports in its own model system. They are not claims about the effects of this product.
For laboratory research use only. Not for human or veterinary use. See our Research Use Only page.